Rituximab Treatment of Patients with Severe, Corticosteroid-Resistant Thyroid-Associated Ophthalmopathy

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thyroid-associated ophthalmopathy in iranian patients

we determined the frequency of clinical thyroid ophthalmopathy in iranian patients. this cross-sectional study was performed at the endocrinology institute of tehran university of medical sciences. all patients with documented thyroid disorders from september 2003 to july 2005 were recruited. eye examinations included evaluation of soft tissue changes, measurement of proptosis, lid width, lagop...

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Treatment of thyroid associated ophthalmopathy with periocular injections of triamcinolone.

AIM To evaluate the efficacy of periocular triamcinolone acetonide for the treatment of thyroid associated ophthalmopathy (TAO), and the presence of ocular or systemic adverse effects. METHODS A multicentre prospective pilot study was performed on patients diagnosed with Graves' ophthalmopathy less than 6 months before entry to the study. Patients were admitted to the study and were randomise...

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Thyroid-associated Ophthalmopathy

Thyroid-associated ophthalmopathy is the most frequent extrathyroidal involvement of Graves' disease but it sometimes occurs in euthyroid or hypothyroid patients. Thyroid-associated ophthalmopathy is an autoimmune disorder, but its pathogenesis is not completely understood. Autoimmunity against putative antigens shared by the thyroid and the orbit plays a role in the pathogenesis of disease. Th...

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Does rituximab improve clinical outcomes of patients with thyroid-associated ophthalmopathy? A systematic review and meta-analysis

BACKGROUND The current therapies of thyroid-associated ophthalmopathy (TAO) were still a challenging matter. In this study, we aimed to contrast the impact of before- after rituximab (RTX) therapy in the patients with TAO. METHODS We searched the PubMed, EMBASE, and SCOPUS databases for articles published up to July 3, 2017. Fixed- or random-effects meta-analysis was used to provide pooled es...

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ژورنال

عنوان ژورنال: Ophthalmology

سال: 2010

ISSN: 0161-6420

DOI: 10.1016/j.ophtha.2009.05.029